human COX4I2 shRNA silencing AAV

Cat. No: shAAV-205829

Availability: 6-8 weeks

Name: AAV-h-COX4I2-shRNA

This is an AAV expressing shRNA for silencing of Human COX4I2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: COX4I2
Gene Name: cytochrome c oxidase subunit 4I2
Gene ID: 84701
Gene Synonyms: COX4; COX4-2; COX4B; COX4L2; COXIV-2; dJ857M17.2
ORF Size: 516 bp
RefSeq#: NM_032609
Gene Description: Cytochrome c oxidase (COX), the terminal enzyme of the mitochondrial respiratory chain, catalyzes the electron transfer from reduced cytochrome c to oxygen. It is a heteromeric complex consisting of 3 catalytic subunits encoded by mitochondrial genes and multiple structural subunits encoded by nuclear genes. The mitochondrially-encoded subunits function in electron transfer, and the nuclear-encoded subunits may be involved in the regulation and assembly of the complex. This nuclear gene encodes isoform 2 of subunit IV. Isoform 1 of subunit IV is encoded by a different gene, however, the two genes show a similar structural organization. Subunit IV is the largest nuclear encoded subunit which plays a pivotal role in COX regulation.
UniGene ID: Hs.277101
HGNC ID: HGNC:16232