human PDCD1 shRNA silencing AAV

Cat. No: shAAV-218432

Availability: 6-8 weeks

Name: AAV-h-PDCD1-shRNA

This is an AAV expressing shRNA for silencing of Human PDCD1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDCD1
Gene Name: programmed cell death 1
Gene ID: 5133
Gene Synonyms: CD279; hPD-1; hPD-l; hSLE1; PD-1; PD1; SLEB2
ORF Size: 867 bp
RefSeq#: NM_005018
Gene Description: PDCD1 encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
UniGene ID: Hs.158297
HGNC ID: HGNC:8760