human PDCD1 Over-expression AAV

Name 
AAV-h-PDCD1
Cat No 
AAV-218432
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human PDCD1.

AAV-218432
AAV-h-PDCD1

Ready-to-use AAV expressing Human PDCD1 (programmed cell death 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD279; CD279; hPD-1; hPD-l; hSLE1; PD1; PD-1; programmed cell death 1 protein; programmed cell death protein 1; protein PD-1; SLEB2; systemic lupus erythematosus susceptibility 2
Description (eCommerce)
PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. PD-1 delivers inhibitory signals upon binding to ligands CD274/PD-L1 and CD273/PD-L2. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15116].
Description (Vector)
PDCD1 encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Gene ID
5133
Gene Name (eCommerce)
programmed cell death 1
Gene Name (Vector)
programmed cell death 1
Gene Symbol
PDCD1
HGNC ID
HGNC:8760
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
867
Protein Name (eCommerce)
Programmed cell death protein 1
RefSeq ID
NM_005018
RefSeq Synonyms
NM_005018, BC074740,
Research Areas
Apoptosis,Immunology,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. PD-1 delivers inhibitory signals upon binding to ligands CD274/PD-L1 and CD273/PD-L2. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15116].
UniGene ID
Hs.158297
UniProt ID (eCommerce)
Q15116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.