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human PDCD1 shRNA silencing AAV

Name 
AAV-h-PDCD1-shRNA
Cat No 
shAAV-218432
Availability
6-8 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human PDCD1.

shAAV-218432
AAV-h-PDCD1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human PDCD1 (programmed cell death 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CD antigen CD279; CD279; hPD-1; hPD-l; hSLE1; PD1; PD-1; programmed cell death 1 protein; programmed cell death protein 1; protein PD-1; SLEB2; systemic lupus erythematosus susceptibility 2
Description (eCommerce)
PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. PD-1 delivers inhibitory signals upon binding to ligands CD274/PD-L1 and CD273/PD-L2. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15116].
Description (Vector)
PDCD1 encodes a cell surface membrane protein of the immunoglobulin superfamily. This protein is expressed in pro-B-cells and is thought to play a role in their differentiation. In mice, expression of this gene is induced in the thymus when anti-CD3 antibodies are injected and large numbers of thymocytes undergo apoptosis. Mice deficient for this gene bred on a BALB/c background developed dilated cardiomyopathy and died from congestive heart failure. These studies suggest that this gene product may also be important in T cell function and contribute to the prevention of autoimmune diseases.
Gene ID
5133
Gene Name (eCommerce)
programmed cell death 1
Gene Name (Vector)
programmed cell death 1
Gene Symbol
PDCD1
HGNC ID
HGNC:8760
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
867
Protein Name (eCommerce)
Programmed cell death protein 1
RefSeq ID
NM_005018
RefSeq Synonyms
NM_005018, BC074740,
Research Areas
Apoptosis,Immunology,Signal Transduction,T-cell Receptor Signaling
Research Areas (Faceted)
signal_transduction,cell_biology,immunology,signal_transduction
Species
human
Target Sentence
PD-1 is a cell surface membrane protein of the immunoglobulin superfamily. It is an inhibitory receptor on antigen activated T-cells that plays a critical role in induction and maintenance of immune tolerance to self. PD-1 delivers inhibitory signals upon binding to ligands CD274/PD-L1 and CD273/PD-L2. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q15116].
UniGene ID
Hs.158297
UniProt ID (eCommerce)
Q15116

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.