human GBA3 shRNA silencing AAV

Cat. No: shAAV-209702

Availability: 6-8 weeks

Name: AAV-h-GBA3-shRNA

This is an AAV expressing shRNA for silencing of Human GBA3.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GBA3
Gene Name: glucosylceramidase beta 3 (gene/pseudogene)
Gene ID: 57733
Gene Synonyms: CBG; CBGL1; GLUC; KLRP
ORF Size: 1410 bp
RefSeq#: NM_020973
Gene Description: GBA3, or cytosolic beta-glucosidase (EC 3.2.1.21), is a predominantly liver enzyme that efficiently hydrolyzes beta-D-glucoside and beta-D-galactoside, but not any known physiologic beta-glycoside, suggesting that it may be involved in detoxification of plant glycosides (de Graaf et al., 2001 (PubMed 11389701)). GBA3 also has significant neutral glycosylceramidase activity (EC 3.2.1.62), suggesting that it may be involved in a nonlysosomal catabolic pathway of glucosylceramide metabolism (Hayashi et al., 2007 (PubMed 17595169)).(supplied by OMIM, Mar 2008)
UniGene ID: Hs.653107
HGNC ID: HGNC:19069