mouse RCOR1 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-270328
Availability:
4-5 weeks
Name:
AAV-m-RCOR1-shRNA
This is an AAV expressing shRNA for silencing of Mouse Rcor1.
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Product Info
- Knockdown
- >90% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Rcor1
- Gene Name
- REST corepressor 1
- Gene ID
- 217864
- Gene Synonyms
- 5730409O11; 6720480E22Rik; AU042633; D12Wsu95e; mKIAA0071; Rocr1
- ORF Size
- 1149 bp
- RefSeq#
- NM_198023
- Gene Description
- Essential component of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it serves as a molecular beacon for the recruitment of molecular machinery, including MeCP2 and SUV39H1, that imposes silencing across a chromosomal interval. Plays a central role in demethylation of Lys-4 of histone H3 by promoting demethylase activity of KDM1A on core histones and nucleosomal substrates. It also protects KDM1A from the proteasome. Component of a RCOR/GFI/KDM1A/HDAC complex that suppresses, via histone deacetylase (HDAC) recruitment, a number of genes implicated in multilineage blood cell development and controls hematopoietic differentiation.
- UniGene ID
- Mm.23808
Related Products
Product | Cat No. |
---|---|
AAV-h-RCOR1 | AAV-220949 |
AAV-m-RCOR1 | AAV-270328 |
Ad-h-RCOR1 | ADV-220949 |
Ad-m-RCOR1 | ADV-270328 |
AAV-h-RCOR1-shRNA | shAAV-220949 |
Ad-h-RCOR1-shRNA | shADV-220949 |
Ad-m-RCOR1-shRNA | shADV-270328 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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