human RCOR1 shRNA silencing AAV

Name 
AAV-h-RCOR1-shRNA
Cat No 
shAAV-220949
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human RCOR1.

shAAV-220949
AAV-h-RCOR1-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RCOR1 (REST corepressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
80
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
COREST; Protein CoREST; RCOR; REST corepressor 1
Description (eCommerce)
CoREST has been identified as a component of a histone deacetylase (HDAC) complex as well as an interacting protein and corepressor of the REST (repressor element 1 silencing transcription factor) transcription factor. HDAC complexes deacetylate chromatin to repress transcription and silence genes. The CoREST complex may be important in restricting gene expression in a tissue-specific manner.
Description (Vector)
RCOR1 encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
Gene ID
23186
Gene Name (eCommerce)
REST corepressor 1
Gene Name (Vector)
REST corepressor 1
Gene Symbol
RCOR1
HGNC ID
HGNC:17441
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
Protein Name (eCommerce)
REST corepressor 1
RefSeq ID
NM_015156
RefSeq Synonyms
NM_015156, BC111590,
Research Areas
Chromatin Remodeling,Histone Modification,Host-Virus Interactions,Huntington's Disease,Immunology,Neurobiology,Neurodegeneration,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation,genetics,infectious_disease,neurobiology,immunology
Species
human
Target Sentence
CoREST has been identified as a component of a histone deacetylase (HDAC) complex as well as an interacting protein and corepressor of the REST (repressor element 1 silencing transcription factor) transcription factor. HDAC complexes deacetylate chromatin to repress transcription and silence genes. The CoREST complex may be important in restricting gene expression in a tissue-specific manner.
UniGene ID
Hs.510521
UniProt ID (eCommerce)
Q9UKL0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.