human RCOR1 Over-expression AAV

Name 
AAV-h-RCOR1
Cat No 
AAV-220949
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RCOR1.

AAV-220949
AAV-h-RCOR1

Ready-to-use AAV expressing Human RCOR1 (REST corepressor 1). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
COREST; Protein CoREST; RCOR; REST corepressor 1
Description (eCommerce)
CoREST has been identified as a component of a histone deacetylase (HDAC) complex as well as an interacting protein and corepressor of the REST (repressor element 1 silencing transcription factor) transcription factor. HDAC complexes deacetylate chromatin to repress transcription and silence genes. The CoREST complex may be important in restricting gene expression in a tissue-specific manner.
Description (Vector)
RCOR1 encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).
Gene ID
23186
Gene Name (eCommerce)
REST corepressor 1
Gene Name (Vector)
REST corepressor 1
Gene Symbol
RCOR1
HGNC ID
HGNC:17441
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1449
ORF Size (bp)
1449 bp
Protein Name (eCommerce)
REST corepressor 1
RefSeq ID
NM_015156
RefSeq Synonyms
NM_015156, BC111590,
Research Areas
Chromatin Remodeling,Histone Modification,Host-Virus Interactions,Huntington's Disease,Immunology,Neurobiology,Neurodegeneration,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,transcription_translation,genetics,infectious_disease,neurobiology,immunology
Species
human
Target Sentence
CoREST has been identified as a component of a histone deacetylase (HDAC) complex as well as an interacting protein and corepressor of the REST (repressor element 1 silencing transcription factor) transcription factor. HDAC complexes deacetylate chromatin to repress transcription and silence genes. The CoREST complex may be important in restricting gene expression in a tissue-specific manner.
UniGene ID
Hs.510521
UniProt ID (eCommerce)
Q9UKL0

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.