human HGF shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-210994
Availability:
5-8 weeks
Name:
Ad-h-HGF-shRNA
This is an Adenovirus expressing shRNA for silencing of Human HGF.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- HGF
- Gene Name
- hepatocyte growth factor
- Gene ID
- 3082
- Gene Synonyms
- DFNB39; F-TCF; HGFB; HPTA; SF
- ORF Size
- 2187 bp
- RefSeq#
- NM_000601
- Gene Description
- Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor. Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration. It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity. Alternative splicing of this gene produces multiple transcript variants encoding different isoforms.
- UniGene ID
- Hs.396530
- HGNC ID
- HGNC:4893
Related Products
Product | Cat No. |
---|---|
AAV-h-HGF | AAV-233950 |
AAV-m-HGF | AAV-261273 |
Ad-h-HGF | ADV-233950 |
Ad-m-HGF | ADV-261273 |
AAV-h-HGF-shRNA | shAAV-210994 |
AAV-m-HGF-shRNA | shAAV-261273 |
Ad-m-HGF-shRNA | shADV-261273 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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