mouse KDM2A Over-expression AAV

Cat. No: AAV-262758

Availability: 3-5 weeks

Name: AAV-m-KDM2A

This is an AAV expressing Mouse Kdm2a.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Kdm2a
Gene Name: lysine (K)-specific demethylase 2A
Gene ID: 225876
Gene Synonyms: 100043628; 5530401A10Rik; AA589516; AW536790; Cxxc8; Fbl11; Fbl7; Fbxl11; Gm4560; Jhdm1; Jhdm1a; lalina
ORF Size: 2508 bp
RefSeq#: BC076576
Gene Description: Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the centromere. Required to sustain centromeric integrity and genomic stability, particularly during mitosis.
UniGene ID: Mm.31941