Rap guanine nucleotide exchange factor (GEF) 4 adenovirus

Product Category: Ready-use human Adenovirus Type5 (dE1/E3)

Gene Name: RAPGEF4/EPAC2

Gene Alias: CGEF2,EPAC2,RAPGEF4,CAMP-GEFII

GeneBank Number: BC024004

Description:

Epac (exchange protein directly activated by cAMP; also designated cAMP-GEFI) and Epac2 (also designated cAMP-GEFII) compose a novel family of cyclic AMP activated guanine-nucleotide exchange factors (GEFs). Both Epac and Epac2 contain cAMP-binding motifs and a motif common to Ras superfamily GEFs. Epac and Epac2 both function to activate Rap1, a Ras-like GTPase that is known to suppress the oncogenic transformation of cells by Ras. Epac is ubiquitously expressed, whereas Epac2 is primarily expressed in the brain and adrenal glands.

Titer: 1x10¹⁰ PFU/ml

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

Availability: In stock, same day shipping available for orders placed before 1PM.

References:

• Rap1 promotes multiple pancreatic islet cell functions and signals through mTOR complex 1 to enhance proliferation
  J Biol Chem. . 2010. 285(21):15777-85

• Rap1 Promotes Multiple Pancreatic Islet Cell Functions and Signals through Mammalian Target of Rapamycin Complex 1 to Enhance Proliferation
  The Journal of Biological Chemistry. 2010. 285:15777-15785.

Catalog No.	Tag	Promoter		Species	Price **
1392		CMV		human	$690.00

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