Src adenovirus

Product Category: Ready-use human Adenovirus Type5 (dE1/E3)

Description:

Several protein tyrosine kinases (Src, Fyn, Lyn, Yes, Lck, Hck, etc) have been identified within the Src gene family. On the basis of their associations with specific cell surface receptors, Src gene family members play critical roles in various signal transduction pathways.

Src is regulated by tyrosine phosphorylation at two sites with opposite effects. Phosphorylation of Tyr 416 in the activation loop of the kinase domain upregulates the enzyme; Phosphorylation of Tyr 527 in the C-terminal by CSK inhibits the enzyme activity.

This adenovirus has a Src activating and signaling molecule.

Titer: 1x10¹⁰ PFU/ml

Volume: 200ul

Storage Buffer: DMEM with 2% BSA & 2.5% Glycerol

Availability: In stock, same day shipping available for orders placed before 1PM.

References:

• ILK mediates the effects of strain on intestinal epithelial wound closure.
  Am J Physiol Cell Physiol.. 2011. 300(2):C356-67

• Eukaryotic translation initiation factor 4E binding protein 1 (4EBP-1) function is suppressed by Src and PP2A on extracellular matrix.
  JBC. 2011. :[epub ahead of print]

Catalog No.	Tag	Promoter		Species	Price **
1166		CMV		Human	$475.00

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