mouse FGFR3 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Mouse Fgfr3.
shADV-259396
Ad-m-FGFR3-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Mouse Fgfr3 (fibroblast growth factor receptor 3). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CD333; Fgfr-3; Flg-2; FR3; HBGFR; Mfr3; sam3
Description (Vector)
Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation and apoptosis. Plays an essential role in the regulation of chondrocyte differentiation, proliferation and apoptosis, and is required for normal skeleton development. Regulates both osteogenesis and postnatal bone mineralization by osteoblasts. Promotes apoptosis in chondrocytes, but can also promote cancer cell proliferation. Required for normal development of the inner ear. Phosphorylates PLCG1, CBL and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Plays a role in the regulation of vitamin D metabolism. Mutations that lead to constitutive kinase activation or impair normal FGFR3 maturation, internalization and degradation lead to aberrant signaling. Over-expressed or constitutively activated FGFR3 promotes activation of PTPN11/SHP2, STAT1, STAT5A and STAT5B.
Gene ID
14184
Gene Name (Vector)
fibroblast growth factor receptor 3
Gene Symbol
Fgfr3
ORF Size (aa)
2403
ORF Size (bp)
2403 bp
RefSeq ID
NM_008010
RefSeq Synonyms
NM_008010, NM_001205270, NM_001163217, NM_001163216, NM_001163215, BC053056,
Species
mouse
UniGene ID
Mm.6904
Recently Viewed Products
Ad-CMV-iCre
Cat No: 1045
Ad-CMV-Caspase 9 (DN)
Cat No: 1044
Ad-CMV-Rb
Cat No: 1043
Ad-CMV-p27
Cat No: 1042
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.