human MBTPS2 shRNA silencing Adenovirus

Product Info

Knockdown

>80% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

MBTPS2

Gene Name

membrane bound transcription factor peptidase, site 2

Gene ID

51360

Gene Synonyms

BRESEK; IFAP; KFSD; KFSDX; OLMSX; S2P

ORF Size

1560 bp

RefSeq#

NM_015884

Gene Description

MBTPS2 encodes a intramembrane zinc metalloprotease, which is essential in development. This protease functions in the signal protein activation involved in sterol control of transcription and the ER stress response. Mutations in this gene have been associated with ichthyosis follicularis with atrichia and photophobia (IFAP syndrome); IFAP syndrome has been quantitatively linked to a reduction in cholesterol homeostasis and ER stress response.

HGNC ID

HGNC:15455