human SARS2 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human SARS2.
shADV-222261
Ad-h-SARS2-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human SARS2 (seryl-tRNA synthetase 2, mitochondrial). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
mtSerRS; SARS; SARSM; SerRS; SerRSmt; SERS; SYS
Description (Vector)
SARS2 encodes the mitochondrial seryl-tRNA synthethase precursor, a member of the class II tRNA synthetase family. The mature enzyme catalyzes the ligation of Serine to tRNA(Ser) and participates in the biosynthesis of selenocysteinyl-tRNA(sec) in mitochondria. The enzyme contains an N-terminal tRNA binding domain and a core catalytic domain. It functions in a homodimeric form, which is stabilized by tRNA binding. SARS2 is regulated by a bidirectional promoter that also controls the expression of mitochondrial ribosomal protein S12. Both genes are within the critical interval for the autosomal dominant deafness locus DFNA4 and might be linked to this disease. Multiple transcript variants encoding different isoforms have been identified for this gene.
Gene ID
54938
Gene Name (Vector)
seryl-tRNA synthetase 2, mitochondrial
Gene Symbol
SARS2
HGNC ID
HGNC:17697
ORF Size (aa)
1557
ORF Size (bp)
1557 bp
RefSeq ID
NM_017827
RefSeq Synonyms
NM_017827, NM_001145901, BC042912,
Species
human
UniGene ID
Hs.709416
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.