human PVRL3 shRNA silencing Adenovirus

Product Info

Knockdown

>90% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Human Adenovirus Type5 (dE1/E3)

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

DMEM, 2% BSA, 2.5% Glycerol

Gene Details

Species

Human

Gene Symbol

NECTIN3

Gene Name

nectin cell adhesion molecule 3

Gene ID

25945

Gene Synonyms

CD113; CDW113; NECTIN-3; PPR3; PRR3; PVRL3; PVRR3

ORF Size

1101 bp

RefSeq#

NM_015480

Gene Description

PVRL3 encodes a member of the nectin family of proteins, which function as adhesion molecules at adherens junctions. This family member interacts with other nectin-like proteins and with afadin, a filamentous actin-binding protein involved in the regulation of directional motility, cell proliferation and survival. PVRL3 plays a role in ocular development involving the ciliary body. Mutations in this gene are believed to result in congenital ocular defects. Alternative splicing results in multiple transcript variants.

UniGene ID

Hs.293917

HGNC ID

HGNC:17664