human FOXO4 shRNA silencing Adenovirus
This is an Adenovirus expressing shRNA for silencing of Human FOXO4.
shADV-209276
Ad-h-FOXO4-shRNA
Ready-to-use Adenovirus expressing shRNA for silencing of Human FOXO4 (forkhead box O4). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
AFX; AFX1; fork head domain transcription factor AFX1; forkhead box protein O4; MLLT7; myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 7
Description (eCommerce)
FOXO4 (fork-head box O4) is a fork-head DNA-binding domain containing protein and functions as a transcription factor involved in the regulation of the insulin signaling pathway. FOXO4 binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. It also down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes, and is involved in the negative regulation of the cell cycle [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P98177].
Description (Vector)
FOXO4 encodes a member of the O class of winged helix/forkhead transcription factor family. Proteins encoded by this class are regulated by factors involved in growth and differentiation indicating they play a role in these processes. A translocation involving this gene on chromosome X and the homolog of the Drosophila trithorax gene, encoding a DNA binding protein, located on chromosome 11 is associated with leukemia. Multiple transcript variants encoding different isoforms have been found for this gene.
Gene ID
4303
Gene Name (eCommerce)
forkhead box O4
Gene Name (Vector)
forkhead box O4
Gene Symbol
FOXO4
HGNC ID
HGNC:7139
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1518
ORF Size (bp)
1518 bp
Protein Name (eCommerce)
Forkhead box protein O4
RefSeq ID
NM_005938
RefSeq Synonyms
NM_005938, NM_001170931, BC106761,
Research Areas
Aging,Angiogenesis,B-cell Receptor Signaling,Cancer,Cell Cycle,DNA Damage/Repair,EGFR Signaling,EGFR Signaling in Cancer,Fc Receptor Signaling,FGF Signaling,FoxO Signaling,Glioma,Immunology,Innate Immunity,Insulin Signaling,Interleukin Signaling,Neurobiology,NGF Signaling,PDGF Signaling,PI3K/Akt Signaling,PI3K-AKT Signaling in Cancer,SCF-KIT Signaling,Signal Transduction,TGF-beta Signaling,Transcription Factor/Regulator
Research Areas (Faceted)
cancer,cell_biology,cell_cycle,developmental_biology,genetics,immunology,neurobiology,signal_transduction,stem_cell_biology,transcription_translation
Species
human
Target Sentence
FOXO4 (fork-head box O4) is a fork-head DNA-binding domain containing protein and functions as a transcription factor involved in the regulation of the insulin signaling pathway. FOXO4 binds to insulin-response elements (IREs) and can activate transcription of IGFBP1. It also down-regulates expression of HIF1A and suppresses hypoxia-induced transcriptional activation of HIF1A-modulated genes, and is involved in the negative regulation of the cell cycle [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P98177].
UniGene ID
Hs.584654
UniProt ID (eCommerce)
P98177
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.