human E2F2 shRNA silencing Adenovirus
Category: Adenovirus > shRNA-Silencing
Cat. No: shADV-207492
Availability:
5-8 weeks
Name:
Ad-h-E2F2-shRNA
This is an Adenovirus expressing shRNA for silencing of Human E2F2.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Human Adenovirus Type5 (dE1/E3)
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- DMEM, 2% BSA, 2.5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- E2F2
- Gene Name
- E2F transcription factor 2
- Gene ID
- 1870
- Gene Synonyms
- E2F-2
- ORF Size
- 1314 bp
- RefSeq#
- NM_004091
- Gene Description
- E2F2 is a member of the E2F family of transcription factors. The E2F family plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses. The E2F proteins contain several evolutionally conserved domains found in most members of the family. These domains include a DNA binding domain, a dimerization domain which determines interaction with the differentiation regulated transcription factor proteins (DP), a transactivation domain enriched in acidic amino acids, and a tumor suppressor protein association domain which is embedded within the transactivation domain. This protein and another 2 members, E2F1 and E2F3, have an additional cyclin binding domain. This protein binds specifically to retinoblastoma protein pRB in a cell-cycle dependent manner, and it exhibits overall 46% amino acid identity to E2F1.
- UniGene ID
- Hs.194333
- HGNC ID
- HGNC:3114
Related Products
Product | Cat No. |
---|---|
AAV-h-E2F2 | AAV-207492 |
AAV-m-E2F2 | AAV-257650 |
Ad-h-E2F2 | ADV-207492 |
Ad-m-E2F2 | ADV-257650 |
AAV-h-E2F2-shRNA | shAAV-207492 |
AAV-m-E2F2-shRNA | shAAV-257650 |
Ad-m-E2F2-shRNA | shADV-257650 |
Control Products
Product | Cat No. |
---|---|
Ad-GFP-U6-shRNA | 1122 |
Ad-U6-Luc-RNAi | 1123 |
Ad-U6-RNAi | 1640 |
Ad-U6-shRNA-CFP | 1780 |
Ad-U6-shRNA-mCherry | 1781 |
Ad-U6-shRNA-RFP | 1782 |
Ad-U6-shRNA-YFP | 1783 |
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