mouse RSPO2 shRNA silencing AAV

Cat. No: shAAV-271186

Availability: 6-8 weeks

Name: AAV-m-RSPO2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Rspo2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Rspo2
Gene Name: R-spondin 2
Gene ID: 239405
Gene Synonyms: 2610028F08Rik; AA673245; D430027K22; ftls
ORF Size: 729 bp
RefSeq#: NM_172815
Gene Description: Activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway and in non-canonical Wnt signaling pathway, probably by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway. Probably also acts as a ligand for frizzled and LRP receptors (By similarity).
UniGene ID: Mm.193274