mouse RNF216 shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Mouse Rnf216.
shAAV-270730
AAV-m-RNF216-shRNA
Ready-to-use AAV expressing shRNA for silencing of Mouse Rnf216 (ring finger protein 216). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
2810055G22Rik; AI647468; AU019462; C86502; F830018F18Rik; TRIAD3; Ubce7ip1; UIP83
Description (Vector)
Isoform 1 acts as an E3 ubiquitin ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Promotes degradation of TRAF3, TLR4 and TLR9. Contributes to the regulation of antiviral responses. Down-regulates activation of NF-kappa-B, IRF3 activation and IFNB production. Isoform 3/ZIN inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis.
Gene ID
108086
Gene Name (Vector)
ring finger protein 216
Gene Symbol
Rnf216
ORF Size (aa)
2562
ORF Size (bp)
2562 bp
RefSeq ID
NM_080561
RefSeq Synonyms
NM_207110, NM_080561, BC065066,
Species
mouse
UniGene ID
Mm.381440
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.