human RNF216 Over-expression AAV

Name 
AAV-h-RNF216
Cat No 
AAV-221411
Availability
4-5 weeks
Categories
AAV, Over-Expression

This is an AAV expressing Human RNF216.

AAV-221411
AAV-h-RNF216

Ready-to-use AAV expressing Human RNF216 (ring finger protein 216). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter
none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
CAHH; E3 ubiquitin-protein ligase RNF216; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; triad domain-containing protein 3; TRIAD3; U7I1; UBCE7IP1; ubiquitin-conjugating enzyme 7-interacting protein 1; ZIN; zinc finger protein inhibiting NF-kappa-B
Description (eCommerce)
Ring finger protein 216 (RNF216) specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains RNF216 are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. RNF216 may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates [taken from NCBI Entrez Gene (Gene ID: 10084)].
Description (Vector)
RNF216 encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known.
Gene ID
54476
Gene Name (eCommerce)
ring finger protein 216
Gene Name (Vector)
ring finger protein 216
Gene Symbol
RNF216
HGNC ID
HGNC:21698
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
2601
ORF Size (bp)
2601 bp
Protein Name (eCommerce)
E3 ubiquitin-protein ligase RNF216
RefSeq ID
NM_207111
RefSeq Synonyms
NM_207116, NM_207111, BC063825,
Research Areas
Apoptosis,Cancer,Host-Virus Interactions,Response to Virus,Signal Transduction,Toll-like Receptor Signaling,Ubiquitination,Zinc-finger
Research Areas (Faceted)
cancer,cell_biology,immunology,infectious_disease,signal_transduction
Species
human
Target Sentence
Ring finger protein 216 (RNF216) specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains RNF216 are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. RNF216 may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates [taken from NCBI Entrez Gene (Gene ID: 10084)].
UniGene ID
Hs.689456
UniProt ID (eCommerce)
Q9NWF9

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About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.