mouse POLR2E shRNA silencing AAV

Cat. No: shAAV-269038

Availability: 4-5 weeks

Name: AAV-m-POLR2E-shRNA

This is an AAV expressing shRNA for silencing of Mouse Polr2e.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Polr2e
Gene Name: polymerase (RNA) II (DNA directed) polypeptide E
Gene ID: 66420
Gene Synonyms: 2410021N14Rik; 25kDa; AW208866; RPB5; XAP4
ORF Size: 489 bp
RefSeq#: NM_025554
Gene Description: DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).
UniGene ID: Mm.18579