mouse HAND2 shRNA silencing AAV

Cat. No: shAAV-261098

Availability: 6-8 weeks

Name: AAV-m-HAND2-shRNA

This is an AAV expressing shRNA for silencing of Mouse Hand2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Hand2
Gene Name: heart and neural crest derivatives expressed transcript 2
Gene ID: 15111
Gene Synonyms: AI225906; AI661148; bHLHa26; dHAND; Ehand2; Hed; Th2; Thing2
ORF Size: 654 bp
RefSeq#: NM_010402
Gene Description: Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Plays also an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity).
UniGene ID: Mm.430844