human KIR2DS2 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-232291
Availability:
6-8 weeks
Name:
AAV-h-KIR2DS2-shRNA
This is an AAV expressing shRNA for silencing of Human KIR2DS2.
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Product Info
- Knockdown
- shRNA screening service available, please inquire about this service or other options.
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- KIR2DS2
- Gene Name
- killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 2
- Gene ID
- 100132285
- Gene Synonyms
- 183ActI; CD158b; CD158J; cl-49; KIR-2DS2; NKAT-5; NKAT5
- ORF Size
- 1017 bp
- RefSeq#
- NM_012312
- Gene Description
- Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.
- UniGene ID
- Hs.
- HGNC ID
- HGNC:6334
Related Products
Product | Cat No. |
---|---|
AAV-h-KIR2DS2 | AAV-232145 |
AAV-h-KIR2DS2 | AAV-232291 |
Ad-h-KIR2DS2 | ADV-232145 |
Ad-h-KIR2DS2 | ADV-232291 |
Ad-h-KIR2DS2-shRNA | shADV-232291 |
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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