human ZBTB7B shRNA silencing AAV

Product Info

Knockdown

>70% knockdown of mRNA in cultured cells

Viral Details

Viral Backbone

Recombinant AAV

AAV-ITR

AAV2

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

Promoter

U6

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Gene Details

Species

Human

Gene Symbol

ZBTB7B

Gene Name

zinc finger and BTB domain containing 7B

Gene ID

51043

Gene Synonyms

c-Krox; DKFZp686G01254; hcKrox; THPOK; ZBTB15; ZFP67; ZNF857B;

ORF Size

1620 bp

RefSeq#

NM_015872

Gene Description

ZBTB7B encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene.

UniGene ID

Hs.700874

HGNC ID

HGNC:18668