human ZBTB7B Adenovirus
This is an Adenovirus expressing Human ZBTB7B.
ADV-228084
Ad-h-ZBTB7B
Ready-to-use Adenovirus expressing Human ZBTB7B (zinc finger and BTB domain containing 7B). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
CKROX; c-KROX; hcKROX; krueppel-related zinc finger protein cKrox; T-helper-inducing POZ/Krueppel-like factor; THPOK; ZBTB15; ZFP67; ZFP-67; zinc finger and BTB domain containing 15; Zinc finger and BTB domain-containing protein 15; zinc finger and BTB domain-containing protein 7B; zinc finger protein 67 homolog; zinc finger protein 857B; zinc finger protein Th-POK; ZNF857B
Description (eCommerce)
ZBTB7B is a transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. ZBTB7B is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is also a transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15156].
Description (Vector)
ZBTB7B encodes a zinc finger-containing transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. It is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. It also functions as a transcriptional repressor of type I collagen genes. Alternatively spliced transcript variants have been found for this gene.
Gene ID
51043
Gene Name (eCommerce)
zinc finger and BTB domain containing 7B
Gene Name (Vector)
zinc finger and BTB domain containing 7B
Gene Symbol
ZBTB7B
HGNC ID
HGNC:18668
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1620
ORF Size (bp)
1620 bp
Protein Name (eCommerce)
Zinc finger and BTB domain-containing protein 7B
RefSeq ID
NM_015872
RefSeq Synonyms
NM_015872, NM_001256455, NM_001252406, BC012070,
Research Areas
Transcription Factor/Regulator,Zinc-finger
Research Areas (Faceted)
cell_biology,transcription_translation
Species
human
Target Sentence
ZBTB7B is a transcription factor that acts as a key regulator of lineage commitment of immature T-cell precursors. ZBTB7B is necessary and sufficient for commitment of CD4 lineage, while its absence causes CD8 commitment. Development of immature T-cell precursors (thymocytes) to either the CD4 helper or CD8 killer T-cell lineages correlates precisely with their T-cell receptor specificity for major histocompatibility complex class II or class I molecules, respectively. ZBTB7B is also a transcriptional repressor of the collagen COL1A1 and COL1A2 genes and may also function as a repressor of fibronectin and possibly other extracellular matrix genes [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ O15156].
UniGene ID
Hs.700874
UniProt ID (eCommerce)
O15156
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.