human UHRF2 shRNA silencing AAV

Name
AAV-h-UHRF2-shRNA

Cat No
shAAV-227166

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human UHRF2.

shAAV-227166

AAV-h-UHRF2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human UHRF2 (ubiquitin like with PHD and ring finger domains 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

NIRF; RNF107; TDRD23; URF2

Description (Vector)

UHRF2 encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.

Gene ID

115426

Gene Name (Vector)

ubiquitin like with PHD and ring finger domains 2

Gene Symbol

UHRF2

HGNC ID

HGNC:12557

ORF Size (aa)

1512

ORF Size (bp)

1512 bp

RefSeq ID

NM_152896

RefSeq Synonyms

NM_152896, BC028397,

Species

human

UniGene ID

Hs.493401

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.