human TOP3A shRNA silencing AAV

Cat. No: shAAV-226206

Availability: 4-5 weeks

Name: AAV-h-TOP3A-shRNA

This is an AAV expressing shRNA for silencing of Human TOP3A.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: TOP3A
Gene Name: topoisomerase (DNA) III alpha
Gene ID: 7156
Gene Synonyms: TOP3; ZGRF7
ORF Size: 3006 bp
RefSeq#: NM_004618
Gene Description: TOP3A encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus reducing the number of supercoils and altering the topology of DNA. This enzyme forms a complex with BLM which functions in the regulation of recombination in somatic cells.
UniGene ID: Hs.592115
HGNC ID: HGNC:11992