human RORC shRNA silencing AAV

Cat. No: shAAV-221499

Availability: 6-8 weeks

Name: AAV-h-RORC-shRNA

This is an AAV expressing shRNA for silencing of Human RORC.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: RORC
Gene Name: RAR related orphan receptor C
Gene ID: 6097
Gene Synonyms: IMD42; NR1F3; RORG; RZR-GAMMA; RZRG; TOR
ORF Size: 1557 bp
RefSeq#: NM_005060
Gene Description: RORC is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.607993
HGNC ID: HGNC:10260