human RNF170 shRNA silencing AAV

Name
AAV-h-RNF170-shRNA

Cat No
shAAV-221377

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RNF170.

shAAV-221377

AAV-h-RNF170-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RNF170 (ring finger protein 170). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

ADSA; SNAX1

Description (Vector)

RNF170 encodes a RING domain-containing protein that resides in the endoplasmic reticulum (ER) membrane. This protein functions as an E3 ubiquitin ligase and mediates ubiquitination and processing of inositol 1,4,5-trisphosphate (IP3) receptors via the ER-associated protein degradation pathway. It is recruited to the activated IP3 receptors by the ERLIN1/ERLIN2 complex to which it is constitutively bound. Mutations in this gene are associated with autosomal dominant sensory ataxia. Alternatively spliced transcript variants have been found for this gene.

Gene ID

81790

Gene Name (Vector)

ring finger protein 170

Gene Symbol

RNF170

HGNC ID

HGNC:25358

ORF Size (aa)

603

RefSeq ID

NM_030954

RefSeq Synonyms

NM_030954, NM_001160225, NM_001160224, NM_001160223, BC032393,

Species

human

UniGene ID

Hs.696153

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.