human RGS13 shRNA silencing AAV

Name
AAV-h-RGS13-shRNA

Cat No
shAAV-221112

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human RGS13.

shAAV-221112

AAV-h-RGS13-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human RGS13 (regulator of G-protein signaling 13). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Description (Vector)

RGS13 is a member of the regulator of G protein signaling (RGS) family. RGS family members share similarity with S. cerevisiae SST2 and C. elegans egl-10 proteins, which contain a characteristic conserved RGS domain. RGS proteins accelerate GTPase activity of G protein alpha-subunits, thereby driving G protein into their inactive GDP-bound form, thus negatively regulating G protein signaling. RGS proteins have been implicated in the fine tuning of a variety of cellular events in response to G protein-coupled receptor activation. The biological function of this gene, however, is unknown. Two transcript variants encoding the same isoform exist.

Gene ID

6003

Gene Name (Vector)

regulator of G-protein signaling 13

Gene Symbol

RGS13

HGNC ID

HGNC:9995

ORF Size (aa)

480

RefSeq ID

NM_002927

RefSeq Synonyms

NM_144766, NM_002927, BC056866, BC016667,

Species

human

UniGene ID

Hs.497220

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.