human PTRF shRNA silencing AAV
This is an AAV expressing shRNA for silencing of Human PTRF.
shAAV-220368
AAV-h-PTRF-shRNA
Ready-to-use AAV expressing shRNA for silencing of Human PTRF (polymerase I and transcript release factor). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
caveolae-associated protein 1; CAVIN; cavin-1; CGL4; congenital generalized lipodystrophy 4; FKSG13; polymerase I and transcript release factor; PTRF; RNA polymerase I and transcript release factor; TTF-I interacting peptide 12
Description (eCommerce)
PTRF (polymerase I and transcript release factor) was first identified as a TTF-I and RNA polymerase I (RNA Pol I) interacting protein that functions in the termination of RNA polymerase I transcription. PTRF has also been described as a protein that localizes to the plasma membrane and caveolae of adipocytes and whose localization is under the control of insulin. In this context, PTRF has been observed to associate with a lipase and have an extranuclear role in the regulation of lipolysis.
Description (Vector)
PTRF encodes a protein that enables the dissociation of paused ternary polymerase I transcription complexes from the 3' end of pre-rRNA transcripts. This protein regulates rRNA transcription by promoting the dissociation of transcription complexes and the reinitiation of polymerase I on nascent rRNA transcripts. This protein also localizes to caveolae at the plasma membrane and is thought to play a critical role in the formation of caveolae and the stabilization of caveolins. This protein translocates from caveolae to the cytoplasm after insulin stimulation. Caveolae contain truncated forms of this protein and may be the site of phosphorylation-dependent proteolysis. This protein is also thought to modify lipid metabolism and insulin-regulated gene expression. Mutations in this gene result in a disorder characterized by generalized lipodystrophy and muscular dystrophy.
Gene ID
284119
Gene Name (eCommerce)
caveolae associated protein 1
Gene Name (Vector)
polymerase I and transcript release factor
Gene Symbol
PTRF
HGNC ID
HGNC:9688
NCBI Taxonomy ID (eCommerce)
9606.0
ORF Size (aa)
1173
ORF Size (bp)
1173 bp
Protein Name (eCommerce)
Polymerase I and transcript release factor
RefSeq ID
NM_012232
RefSeq Synonyms
NM_012232, BC073759, BC066123, BC008849,
Research Areas
Cell Biology,EGFR Signaling,Gene Expression,Mitochondrion,RNA Binding,RNA Processing,Signal Transduction,Transcription Factor/Regulator
Research Areas (Faceted)
cell_biology,genetics,signal_transduction,transcription_translation
Species
human
Target Sentence
PTRF (polymerase I and transcript release factor) was first identified as a TTF-I and RNA polymerase I (RNA Pol I) interacting protein that functions in the termination of RNA polymerase I transcription. PTRF has also been described as a protein that localizes to the plasma membrane and caveolae of adipocytes and whose localization is under the control of insulin. In this context, PTRF has been observed to associate with a lipase and have an extranuclear role in the regulation of lipolysis.
UniGene ID
Hs.437191
UniProt ID (eCommerce)
Q6NZI2
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About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.