human PDE11A shRNA silencing AAV

Cat. No: shAAV-218459

Availability: 6-8 weeks

Name: AAV-h-PDE11A-shRNA

This is an AAV expressing shRNA for silencing of Human PDE11A.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: PDE11A
Gene Name: phosphodiesterase 11A
Gene ID: 50940
Gene Synonyms: PPNAD2
ORF Size: 2805 bp
RefSeq#: NM_016953
Gene Description: The 3',5'-cyclic nucleotides cAMP and cGMP function as second messengers in a wide variety of signal transduction pathways. 3',5'-cyclic nucleotide phosphodiesterases (PDEs) catalyze the hydrolysis of cAMP and cGMP to the corresponding 5'-monophosphates and provide a mechanism to downregulate cAMP and cGMP signaling. This gene encodes a member of the PDE protein superfamily. Mutations in this gene are a cause of Cushing disease and adrenocortical hyperplasia. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.570273
HGNC ID: HGNC:8773