human OSBPL2 shRNA silencing AAV

Cat. No: shAAV-217949

Availability: 6-8 weeks

Name: AAV-h-OSBPL2-shRNA

This is an AAV expressing shRNA for silencing of Human OSBPL2.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: OSBPL2
Gene Name: oxysterol binding protein like 2
Gene ID: 9885
Gene Synonyms: DFNA67; DNFA67; ORP-2; ORP2
ORF Size: 1443 bp
RefSeq#: NM_144498
Gene Description: OSBPL2 encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain, although some members contain only the sterol-binding domain. This encoded protein contains only the sterol-binding domain. In vitro studies have shown that the encoded protein can bind strongly to phosphatic acid and weakly to phosphatidylinositol 3-phosphate, but cannot bind to 25-hydroxycholesterol. The protein associates with the Golgi apparatus. Transcript variants encoding different isoforms have been described.
UniGene ID: Hs.473254
HGNC ID: HGNC:15761