human OGDH shRNA silencing AAV

Cat. No: shAAV-217373

Availability: 4-5 weeks

Name: AAV-h-OGDH-shRNA

This is an AAV expressing shRNA for silencing of Human OGDH.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: OGDH
Gene Name: oxoglutarate dehydrogenase
Gene ID: 4967
Gene Synonyms: AKGDH; E1k; OGDC
ORF Size: 3072 bp
RefSeq#: NM_002541
Gene Description: OGDH encodes one subunit of the 2-oxoglutarate dehydrogenase complex. This complex catalyzes the overall conversion of 2-oxoglutarate (alpha-ketoglutarate) to succinyl-CoA and CO(2) during the Krebs cycle. The protein is located in the mitochondrial matrix and uses thiamine pyrophosphate as a cofactor. A congenital deficiency in 2-oxoglutarate dehydrogenase activity is believed to lead to hypotonia, metabolic acidosis, and hyperlactatemia. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
UniGene ID: Hs.488181
HGNC ID: HGNC:8124