human NT5C3 shRNA silencing AAV

Cat. No: shAAV-217138

Availability: 6-8 weeks

Name: AAV-h-NT5C3-shRNA

This is an AAV expressing shRNA for silencing of Human NT5C3A.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: NT5C3A
Gene Name: 5'-nucleotidase, cytosolic IIIA
Gene ID: 51251
Gene Synonyms: cN-III; hUMP1; NT5C3; p36; P5'N-1; P5N-1; PN-I; POMP; PSN1; UMPH; UMPH1
ORF Size: 894 bp
RefSeq#: NM_016489
Gene Description: NT5C3 encodes a member of the 5'-nucleotidase family of enzymes that catalyze the dephosphorylation of nucleoside 5'-monophosphates. The encoded protein is the type 1 isozyme of pyrimidine 5' nucleotidase and catalyzes the dephosphorylation of pyrimidine 5' monophosphates. Mutations in this gene are a cause of hemolytic anemia due to uridine 5-prime monophosphate hydrolase deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and pseudogenes of this gene are located on the long arm of chromosomes 3 and 4.
UniGene ID: Hs.487933
HGNC ID: HGNC:17820