human KREMEN2 shRNA silencing AAV

Name
AAV-h-KREMEN2-shRNA

Cat No
shAAV-213366

Availability
6-8 weeks

This is an AAV expressing shRNA for silencing of Human KREMEN2.

shAAV-213366

AAV-h-KREMEN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human KREMEN2 (kringle containing transmembrane protein 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

U6 ()

Reporter

eGFP (default), optional CFP, YFP, RFP, mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

KRM2

Description (Vector)

KREMEN2 encodes a high-affinity dickkopf homolog 1 (DKK1) transmembrane receptor. A similar protein in mouse functions interacts with with DKK1 to block wingless (WNT)/beta-catenin signaling. The encoded protein forms a ternary membrane complex with DKK1 and the WNT receptor lipoprotein receptor-related protein 6 (LRP6), and induces rapid endocytosis and removal of LRP6 from the plasma membrane. It contains extracellular kringle, WSC, and CUB domains. Alternatively spliced transcript variants encoding distinct isoforms have been observed for this gene.

Gene ID

79412

Gene Name (Vector)

kringle containing transmembrane protein 2

Gene Symbol

KREMEN2

HGNC ID

HGNC:18797

ORF Size (aa)

1200

ORF Size (bp)

1200 bp

RefSeq ID

NM_024507

RefSeq Synonyms

NM_172229, NM_024507, NM_001253726, NM_001253725, BC009383, BC003533,

Species

human

UniGene ID

Hs.661128

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.