human HYAL1 shRNA silencing AAV

Cat. No: shAAV-211727

Availability: 6-8 weeks

Name: AAV-h-HYAL1-shRNA

This is an AAV expressing shRNA for silencing of Human HYAL1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: HYAL1
Gene Name: hyaluronoglucosaminidase 1
Gene ID: 3373
Gene Synonyms: HYAL-1; LUCA1; MGC45987; NAT6;
ORF Size: 1308 bp
RefSeq#: NM_007312
Gene Description: HYAL1 encodes a lysosomal hyaluronidase. Hyaluronidases intracellularly degrade hyaluronan, one of the major glycosaminoglycans of the extracellular matrix. Hyaluronan is thought to be involved in cell proliferation, migration and differentiation. This enzyme is active at an acidic pH and is the major hyaluronidase in plasma. Mutations in this gene are associated with mucopolysaccharidosis type IX, or hyaluronidase deficiency. The gene is one of several related genes in a region of chromosome 3p21.3 associated with tumor suppression. Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.75619
HGNC ID: HGNC:5320