human GABBR1 shRNA silencing AAV

Cat. No: shAAV-209497

Availability: 6-8 weeks

Name: AAV-h-GABBR1-shRNA

This is an AAV expressing shRNA for silencing of Human GABBR1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: GABBR1
Gene Name: gamma-aminobutyric acid type B receptor subunit 1
Gene ID: 2550
Gene Synonyms: GABABR1; GABBR1-3; GB1; GPRC3A
ORF Size: 2535 bp
RefSeq#: NM_001470
Gene Description: Gamma-aminobutyric acid (GABA) is the main inhibitory neurotransmitter in the mammalian central nervous system. GABA exerts its effects through ionotropic (GABA(A/C)) receptors, to produce fast synaptic inhibition, and metabotropic (GABA(B)) receptors, to produce slow, prolonged inhibitory signals. The GABA(B) receptor consists of a heterodimer of two related 7-transmembrane receptors, GABA(B) receptor 1 and GABA(B) receptor 2. The GABA(B) receptor 1 gene is mapped to chromosome 6p21.3 within the HLA class I region close to the HLA-F gene. Susceptibility loci for multiple sclerosis, epilepsy, and schizophrenia have also been mapped in this region. Alternative splicing of this gene generates multiple transcript variants.
UniGene ID: Hs.167017
HGNC ID: HGNC:4070