human FREM1 shRNA silencing AAV

Cat. No: shAAV-209306

Availability: 6-8 weeks

Name: AAV-h-FREM1-shRNA

This is an AAV expressing shRNA for silencing of Human FREM1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: FREM1
Gene Name: FRAS1 related extracellular matrix 1
Gene ID: 158326
Gene Synonyms: BNAR; C9orf143; C9orf145; C9orf154; MOTA; TILRR; TRIGNO2
ORF Size: 6537 bp
RefSeq#: NM_144966
Gene Description: FREM1 encodes a basement membrane protein that may play a role in craniofacial and renal development. Mutations in this gene have been associated with bifid nose with or without anorectal and renal anomalies. Alternatively spliced transcript variants encoding different isoforms have been described. PubMed ID 19940113 describes one such variant that initiates transcription within a distinct, internal exon; the resulting shorter isoform (named Toll-like/interleukin-1 receptor regulator, TILRR) is suggested to be a co-receptor of the interleukin 1 receptor family and may regulate receptor function and Toll-like receptor/interleukin 1 receptor signal transduction, contributing to the control of inflammatory response activation.
UniGene ID: Hs.709555
HGNC ID: HGNC:23399