human ERLIN2 shRNA silencing AAV
Category: AAV > shRNA-Silencing
Cat. No: shAAV-208080
Availability:
4-5 weeks
Name:
AAV-h-ERLIN2-shRNA
This is an AAV expressing shRNA for silencing of Human ERLIN2.
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Product Info
- Knockdown
- >70% knockdown of mRNA in cultured cells
Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- U6
- Reporter
- eGFP (default), optional CFP, YFP, RFP, mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Human
- Gene Symbol
- ERLIN2
- Gene Name
- ER lipid raft associated 2
- Gene ID
- 11160
- Gene Synonyms
- C8orf2; Erlin-2; NET32; SPFH2; SPG18
- ORF Size
- 621 bp
- RefSeq#
- NM_007175
- Gene Description
- ERLIN2 encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
- UniGene ID
- Hs.705490
- HGNC ID
- HGNC:1356
Related Products
Control Products
Product | Cat No. |
---|---|
AAV1-GFP-U6-shRNA | 7040 |
AAV2-GFP-U6-shRNA | 7041 |
AAV5-GFP-U6-shRNA | 7042 |
AAV6-GFP-U6-shRNA | 7043 |
AAV9-GFP-U6-shRNA | 7045 |
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