human ERLIN2 Over-expression AAV

Name
AAV-h-ERLIN2

Cat No
AAV-208080

Availability
4-5 weeks

This is an AAV expressing Human ERLIN2.

AAV-208080

AAV-h-ERLIN2

Ready-to-use AAV expressing Human ERLIN2 (ER lipid raft associated 2). Available with optional GFP reporter or cell-specific promoter.

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Vector Designer

Product Details

AAV Serotype

Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids

AAV ITR

AAV2

Promoter

CMV (default), or choose from 30 different ubiquitous or cell specific promoter

Reporter

none, optional GFP, CFP, YFP, RFP or mCherry

Storage Buffer

PBS/5% Glycerol

Viral Backbone

Recombinant AAV

Gene Reference Data

Alternate Names

C8orf2; Erlin-2; NET32; SPFH2; SPG18

Description (Vector)

ERLIN2 encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Gene ID

11160

Gene Name (Vector)

ER lipid raft associated 2

Gene Symbol

ERLIN2

HGNC ID

HGNC:1356

ORF Size (aa)

621

ORF Size (bp)

621 bp

RefSeq ID

NM_007175

RefSeq Synonyms

NM_007175, NM_001003791, NM_001003790, BC067765,

Species

human

UniGene ID

Hs.705490

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.