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human ERLIN2 shRNA silencing AAV

Name 
AAV-h-ERLIN2-shRNA
Cat No 
shAAV-208080
Availability
4-5 weeks
Categories
AAV, shRNA-Silencing

This is an AAV expressing shRNA for silencing of Human ERLIN2.

shAAV-208080
AAV-h-ERLIN2-shRNA

Ready-to-use AAV expressing shRNA for silencing of Human ERLIN2 (ER lipid raft associated 2). Available with optional GFP reporter or cell-specific promoter.

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Product Details

AAV Serotype
Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
AAV ITR
AAV2
Promoter
U6 ()
Reporter
eGFP (default), optional CFP, YFP, RFP, mCherry
shRNA Knockdown (%)
70
Storage Buffer
PBS/5% Glycerol
Viral Backbone
Recombinant AAV

Gene Reference Data

Alternate Names
C8orf2; Erlin-2; NET32; SPFH2; SPG18
Description (Vector)
ERLIN2 encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18). Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Gene ID
11160
Gene Name (Vector)
ER lipid raft associated 2
Gene Symbol
ERLIN2
HGNC ID
HGNC:1356
ORF Size (aa)
621
ORF Size (bp)
621 bp
RefSeq ID
NM_007175
RefSeq Synonyms
NM_007175, NM_001003791, NM_001003790, BC067765,
Species
human
UniGene ID
Hs.705490

About Storage Conditions

All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity. We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.