human COL25A1 shRNA silencing AAV

Cat. No: shAAV-205701

Availability: 6-8 weeks

Name: AAV-h-COL25A1-shRNA

This is an AAV expressing shRNA for silencing of Human COL25A1.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: COL25A1
Gene Name: collagen type XXV alpha 1 chain
Gene ID: 84570
Gene Synonyms: AMY; CFEOM5; CLAC; CLAC-P; CLACP
ORF Size: 1491 bp
RefSeq#: NM_032518
Gene Description: COL25A1 encodes a brain-specific membrane associated collagen. A product of proteolytic processing of the encoded protein, CLAC (collagenous Alzheimer amyloid plaque component), binds to amyloid beta-peptides found in Alzheimer amyloid plaques but CLAC inhibits rather than facilitates amyloid fibril elongation (PMID: 16300410). A study of over-expression of this collagen in mice, however, found changes in pathology and behavior suggesting that the encoded protein may promote amyloid plaque formation (PMID: 19548013). Multiple transcript variants encoding different isoforms have been found for this gene.
UniGene ID: Hs.658842
HGNC ID: HGNC:18603