human CD86 shRNA silencing AAV

Cat. No: shAAV-204693

Availability: 6-8 weeks

Name: AAV-h-CD86-shRNA

This is an AAV expressing shRNA for silencing of Human CD86.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: CD86
Gene Name: CD86 molecule
Gene ID: 942
Gene Synonyms: B7-2; B7.2; B70; CD28LG2; LAB72
ORF Size: 990 bp
RefSeq#: NM_006889
Gene Description: CD86 encodes a type I membrane protein that is a member of the immunoglobulin superfamily. This protein is expressed by antigen-presenting cells, and it is the ligand for two proteins at the cell surface of T cells, CD28 antigen and cytotoxic T-lymphocyte-associated protein 4. Binding of this protein with CD28 antigen is a costimulatory signal for activation of the T-cell. Binding of this protein with cytotoxic T-lymphocyte-associated protein 4 negatively regulates T-cell activation and diminishes the immune response. Alternative splicing results in several transcript variants encoding different isoforms.
UniGene ID: Hs.171182
HGNC ID: HGNC:1705