human BRWD2 shRNA silencing AAV

Cat. No: shAAV-202292

Availability: 4-5 weeks

Name: AAV-h-BRWD2-shRNA

This is an AAV expressing shRNA for silencing of Human WDR11.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: WDR11
Gene Name: WD repeat domain 11
Gene ID: 55717
Gene Synonyms: BRWD2; DR11; HH14; SRI1; WDR15
ORF Size: 3675 bp
RefSeq#: NM_018117
Gene Description: WDR11 encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. WDR11 is located in the chromosome 10q25-26 region, which is frequently deleted in gliomas and tumors of other tissues, and is disrupted by the t(10;19) translocation rearrangement in glioblastoma cells. The gene location suggests that it is a candidate gene for the tumor suppressor locus.
UniGene ID: Hs.144447
HGNC ID: HGNC:13831