human ACE shRNA silencing AAV

Cat. No: shAAV-200182

Availability: 6-8 weeks

Name: AAV-h-ACE-shRNA

This is an AAV expressing shRNA for silencing of Human ACE.

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Knockdown: shRNA screening service available, please inquire about this service or other options.

Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: U6
Reporter: eGFP (default), optional CFP, YFP, RFP, mCherry
Storage Buffer: PBS/5% Glycerol

Species: Human
Gene Symbol: ACE
Gene Name: angiotensin I converting enzyme
Gene ID: 1636
Gene Synonyms: ACE1; CD143; DCP; DCP1
ORF Size: 2220 bp
RefSeq#: NM_000789
Gene Description: ACE encodes an enzyme involved in catalyzing the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This enzyme plays a key role in the renin-angiotensin system. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme or cardiovascular pathophysiologies. Multiple alternatively spliced transcript variants encoding different isoforms have been identified, and two most abundant spliced variants encode the somatic form and the testicular form, respectively, that are equally active.
UniGene ID: Hs.654434
HGNC ID: HGNC:2707