mouse USP5 Over-expression AAV

Cat. No: AAV-275751

Availability: 3-5 weeks

Name: AAV-m-USP5

This is an AAV expressing Mouse Usp5.

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Viral Backbone: Recombinant AAV
AAV-ITR: AAV2
AAV Serotype: Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
Promoter: CMV (default), or choose from 30 different ubiquitous or cell specific promoter
Reporter: none, optional GFP, CFP, YFP, RFP or mCherry
Storage Buffer: PBS/5% Glycerol

Species: Mouse
Gene Symbol: Usp5
Gene Name: ubiquitin specific peptidase 5 (isopeptidase T)
Gene ID: 22225
Gene Synonyms: AA407472; ISOT; ISOT-1; Ucht
ORF Size: 2577 bp
RefSeq#: BC066993
Gene Description: Cleaves linear and branched multiubiquitin polymers with a marked preference for branched polymers. Involved in unanchored 'Lys-48'-linked polyubiquitin disassembly. Binds linear and 'Lys-63'-linked polyubiquitin with a lower affinity. Knock-down of USP5 causes the accumulation of p53/TP53 and an increase in p53/TP53 transcriptional activity because the unanchored polyubiquitin that accumulates is able to compete with ubiquitinated p53/TP53 but not with MDM2 for proteasomal recognition.
UniGene ID: Mm.3571