mouse RIPK3 Over-expression AAV
Category: AAV > Over-Expression
Cat. No: AAV-270614
Availability:
Immediate
Name:
AAV-m-RIPK3
This is an AAV expressing Mouse Ripk3.
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Viral Details
- Viral Backbone
- Recombinant AAV
- AAV-ITR
- AAV2
- AAV Serotype
- Available in AAV1, AAV2, AAV3, AAV5, AAV6, AAV8, AAV9, AAV-DJ, AAV-DJ8, AAV-DJ9 and other wildtype/synthetic AAV capsids
- Promoter
- CMV (default), or choose from 30 different ubiquitous or cell specific promoter
- Reporter
- none, optional GFP, CFP, YFP, RFP or mCherry
- Storage Buffer
- PBS/5% Glycerol
Gene Details
- Species
- Mouse
- Gene Symbol
- Ripk3
- Gene Name
- receptor-interacting serine-threonine kinase 3
- Gene ID
- 56532
- Gene Synonyms
- 2610528K09Rik; AW107945; Rip3
- ORF Size
- 1461 bp
- RefSeq#
- BC029210
- Gene Description
- Essential for cellular necroptosis in response to TNF-alpha family of death-inducing cytokines. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production (By similarity).
- UniGene ID
- Mm.46612
Related Products
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