mouse PSEN1 Over-expression AAV
This is an AAV expressing Mouse Psen1.
AAV-269592
AAV-m-PSEN1
Ready-to-use AAV expressing Mouse Psen1 (presenilin 1). Available with optional GFP reporter or cell-specific promoter.
Gene Reference Data
Alternate Names
Ad3h; PS-1; PS1; S182
Description (Vector)
Probable catalytic subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Requires the other members of the gamma-secretase complex to have a protease activity. May play a role in intracellular signaling and gene expression or in linking chromatin to the nuclear membrane. Stimulates cell-cell adhesion though its association with the E-cadherin/catenin complex. Under conditions of apoptosis or calcium influx, cleaves E-cadherin promoting the disassembly of the E-cadherin/catenin complex and increasing the pool of cytoplasmic beta-catenin, thus negatively regulating Wnt signaling. May also play a role in hematopoiesis.
Gene ID
19164
Gene Name (Vector)
presenilin 1
Gene Symbol
Psen1
ORF Size (aa)
1404
ORF Size (bp)
1404 bp
RefSeq ID
NM_008943
RefSeq Synonyms
NM_008943, BC071233, BC030409, BC014744,
Species
mouse
UniGene ID
Mm.998
About Storage Conditions
All our viral products should be kept at -80°C. At this temperature, the virus will remain stable for 6-12 months (and in some cases, up to 2 years). Once thawed, the product can be stored at 4°C for 2-3 weeks without significant loss of biological activity.
We recommend aliquoting your vectors into low protein binding tubes upon receipt. This helps avoid repeated freeze-thaw cycles, as well as prevent loss of virus. To maintain accurate titer, aliquot in at least 20ul per tube.